Functions of the central nervous system are suppressed by the
administration of a type of drug derived from barbituric acid, known
as barbiturate anticonvulsant drugs. The GABA is the chief inhibitory
compound in the mature vertebrate central nervous system that
responds to the neurotransmitter gamma-aminobutyric acid (GABA). The
action of GABA is enhanced by barbiturate anticonvulsants. Seizure is
a sudden attack of illness, especially a stroke or an epileptic fit.
Also, GABA inhibits initiation of discharge that would start the
seizure, as it is an inhibitory neurotransmitter. Effectiveness of
GABA is increased as barbiturate facilitates GABA-mediated opening of
chloride channels. Except absence seizures, all other types of
seizures can be treated by barbiturates.
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Seizures are also known as convulsions. A patients under seizure
loses control over his actions due to sudden attack of brain
activity. During seizure, patients experience jerking of legs, arms,
or face. Various types of seizures may occur to people, irrespective
of age, and can last for few seconds to minutes. Minor seizure can
also be extremely risky when it occurs to a person while driving or
swimming. Seizures that affect only one part of the brain are known
as simple partial seizures or simple focal seizures. During seizure,
there may be loss of awareness, loss of memory, or mental confusion;
such seizures are known as dyscognitive focal seizures.
Rising prevalence of seizures across the world is driving the growth
of the global barbiturate anticonvulsant drugs market. According to
Healthline Media and Epilepsy Foundation of America, who forecasted
same thing that every year, approximately 150,000 people in the U.S.
are diagnosed with central nervous system disorders which lead to
seizures. Healthline Media also states that one in 26 people will be
diagnosed with seizures over a lifetime. Epilepsy is defined as
having two or more unprovoked seizures. According to the World Health
Organization (WHO), up to 10% of the world population has one seizure
during a lifetime. The WHO also states that there are about 50
million people worldwide presently living with epilepsy. Every year,
30 to 50 per 100000 people are newly diagnosed with epilepsy in
high-income countries, and this count is approximately two times
higher among low and middle income countries. Ketogenic diet is
anticipated to restrain the growth of the global barbiturate
anticonvulsants drugs market to a certain extent. According to a
study published by the National Center for Biotechnology Information,
ketogenic diet reduces the chances of seizures in children.
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The global barbiturate anticonvulsant drugs market can be categorized
into indication, distribution channel, and region. In terms of
indication, the market can be classified into generalized seizures
and focal (partial) seizures. Generalized seizures can further be
classified into tonic-clonic seizure, atonic seizure, myoclonic
seizure, clonic seizure, and tonic seizure. Focal seizures can
further be classified into dyscognitive focal seizures and simple
focal seizures. Based on distribution channel, the barbiturate
anticonvulsant drugs market can be divided into retail pharmacies,
online pharmacies, and hospital pharmacies.
Geographically, the global barbiturate anticonvulsant drugs market
can be categorized into Latin America, Asia Pacific, Europe, North
America, and Middle East & Africa. North America held the large
market share in 2017, due to new drug launches and increase in
research and development on barbiturate anticonvulsant drugs in the
region. Europe held the second leading market share in 2017, owing to
increase in awareness programs and promotional activities conducted
by the key players in the region. Asia Pacific is anticipated to grow
at a significant rate during the forecast period owing to increase in
government initiatives to create awareness regarding the barbiturate
anticonvulsant drugs, especially in countries, such as China and
India. Japan held the maximum share of the barbiturate anticonvulsant
drugs market in Asia Pacific in 2017, owing to the large geriatric
population in the country. The barbiturate anticonvulsant drugs
market in Middle East & Africa and Latin America is anticipated
to grow at a moderate rate during the forecast period owing to rise
in government initiatives regarding development of and creating
awareness barbiturate anticonvulsants drugs in the regions.
Key players operating in the global barbiturate anticonvulsants drugs
market include GlaxoSmithKline plc, Astellas Pharma Technologies
Inc., Valeant Pharmaceuticals N.A., and Watson Laboratories, Inc.
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