Dental Pain - Demand for Better and Painless Diagnostics has Resulted in Technological Advancements and High Demand for Restorative Dental Treatment

The dental pain market, according to industry analysts, is ripe with immediate opportunities for new players and new classes of drugs and therapeutics targeting dental pain management.

The leading causes of dental pain include occlusal trauma, periodontal abscess, pulpitis, apical periodontitis, and alveolar osteitis. Pain can also be caused by non-dental reasons such as maxillary sinusitis, muscle pain, angina pectoris, tumors, and psychological disorders. Treatment modules such as phototherapy, root canal treatment, antifungals, antibiotics such as amoxicillin, penicillin, and cindamycin, fluoride application, and antiseptics are used to address dental pain.

Rising Prevalence of Oral Diseases Worldwide Fueling Dental Pain Market

According to the World Health Organization, almost 100% adults and an estimated 60%-90% of school children have dental cavities. Severe periodontal disease is found in 15%-20% of middle-aged adults. Around 16%-40% of children between the ages of 6 to 12 are affected by dental trauma caused by unsafe schools, unsafe playgrounds, violence, or road accidents.

According to the Centers for Disease Control and Prevention, an estimated 47.2% of adults in above the age of 30 and 70.1% of adults above the age of 65 in the U.S. have some form of periodontal disease. The burden of oral diseases and disorders has resulted in the growth of the global dental pain market.

Strong Efforts by Companies and Research Institutes Boosting Development in the Field of Dental Pain Management and Therapeutics

One of the major factors that has led to remarkable development in the field of dental pain management is the consistent research efforts and clinical trials by major companies and top institutes and government bodies.

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Jean Brown Research, Eli Lilly and Company, C. H. Boehringer Sohn AG & Co. KG, Johnson & Johnson, Pfizer Inc., Merck & Co., Inc., Bayer AG, Amgen Inc., Premier Research Group Limited, and GlaxoSmithKline Plc are some of the leading companies involved in clinical trials dealing with dental pain management.

On the other hand, some of the top universities and government associations working on clinical trials on dental pain therapeutics are Islamic Azad University, Khorasgan Branch, Isfahan University of Medical Sciences, Nippon Dental University School of Life Dentistry, Kermanshah University of Medical Sciences, Hamedan University of Medical Sciences, Zahedan University of Medical Sciences, Babol University of Medical Sciences, Shiraz University of Medical Sciences, The University of Hong Kong, and Islamic Azad University, Tehran.

Other factors that contribute towards the growth of the dental pain market include higher purchasing power, supportive government initiatives, extensive reforms, rising demand for restorative dental treatment, technological advancements in oral health and dental surgery, surging demand for improved and painless diagnostics, availability of specialized resources, and better reimbursement services.

Asia Pacific has been identified as one of the most lucrative markets for dental pain management and therapeutics, given the rising population with oral health problems and increase in disposable income.

 The pain management market, on the whole, is admittedly a mature market, which allows players to come up with new therapies that are more efficacious than existing medications.  

Hybrid Tissue - Engineered Bioprostheses – Evolution due to New Emergence in Technologies with Novel Innovations

Bioprosthetics are the material obtained from human or other species for medical implantations. Bioprostheses has shown significant advances from past few years, as their basic characteristic, they become degraded until their complete elimination in the host body. Bioprosthesis will gradually degrade in the recipient will determine the formation of a neotissue in its place, which will completely replace the biomaterial in the long term. Ideally , the bioprosthetics are to achieve not only the repair of the damaged zone but also the regeneration of an adequately organized tissue that will promote angiogenesis and even recruit growth factors acquiring characteristics similar to those of healthy tissue.

The raising prevalence of cardiovascular disorders, such as coronary and peripheral artery diseases, rheumatoid heart disease, and equivalently the demand for prolong relief is expected to broaden the base for the bioprosthetics market. Since the bioprothetic products are made up of biological materials, rate of rejection of implants is comparatively less than that of synthetic implants. The increasing aging population indicated with a raising degenerative cardiac diseases is fueling the bioprosthetic market. Whereas major factors that negatively affect the growth of this market include need of multiple surgeries, threat of infections and incompatibility (tissue rejection), irreversible nature and threat of uneven skin tone and scars after surgeries.

The new emergence in technologies with the novel innovations has evolve the progress in the field hybrid tissue-engineered bioprostheses, in which non-biodegradable cultured tissue scaffolds are used. These hybrid tissue-engineered bioprostheses are with high resistance and durability and can be alternatives for the biodegradable tissue-engineered prosthetics. The new technology which provide a sense of touch to the bio-prosthetics limb is being develop, which would revolutionize this field and allow many patients with limited options for restoring function to have near normal life-experiences. These technological advancements are expected to potentially decrease the morbidity and mortality rate associated with heart valve disorders, abdominal wall diseases, orthopedic disorders and others, which are expected to increase the share of bioprosthetics market.

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The global bioprosthetic market can be segmented based on origin, applications, and geography. Applications segment comprises cardiovascular, nephrological, orthopedics, neurological, urogenital, ophthalmic, and others. Bioprosthetic according to the origin are classified as xenogenic (animal origin), allogenic (human origin), and tissue source (dermis, pericardium, or intestinal submucosa). Geographically, the bioprosthetic market is segmented into North America, Europe, Asia Pacific, and Middle-east and Africa. Where North America is expected to be the largest regional market for bioprosthetic market due to an increase technological innovations raising cardiovascular and orthopedic procedures. North America is a potential market for advanced products manufactured through innovation and transforming bioprosthetic technology. Europe accounts at the second largest position in the bioprosthetic market globally. Followed by Europe, the emerging economies in Asia Pacific and Latin America hold immense potential for the bioprosthetic market. The factors like increasing population, rise in incidence of obesity, rising incidences of road accidents with the high unmet medical needs and developing healthcare infrastructure are major drivers for the bioprosthetics in the emerging market

Some key players of the bioprosthetics market include Life Cell Corporation, Edwards Lifesciences Corporation, LeMaitre Vascular, Inc., CryoLife, Inc., Labcor Laboratorios Ltd., Maquet Metinge Group, Organogenesis, Inc., Braile Biomedica, Inc., Medtronic Plc., Humacyte, Inc., Aortech International Plc, JenaValve Technology GmbH, Sorin Group, Ethicon, Inc., St. Jude Medical, Inc., and others.

 These key players are focusing on implementing the strategies like geographical expansion, new product launch, and strategic acquisitions and collaborations, to make strong hold on existing market and to explore the potential emerging markets.

IoT in Healthcare - Major Technological Advancements in Field of Healthcare Software and Medical devices shows its Rapid Growth in North America

Internet of Things (IoT) refers to the concept of connecting several devices to the internet which operated previously as stand-alone units without any interconnectivity. Sensors based on micro-electromechanical systems are being deployed widely for IoT applications. Increasing innovations in higher performance, lower cost, smaller, and more robust IoT sensors are continuing to spur the demand for these sensors and the systems in which they are deployed. The established MEMS-based IoT sensors are being adopted widely into diverse application areas. The major application areas these sensors include automotive, consumer electronics, industrial, retail, safe & security, healthcare, power & utilities and building & home automation among others.

The proliferation of the Internet of Things (IoT) in the healthcare market, which comprises systems and software, medical devices, and services, has had a significant impact on the overall healthcare sector and been immensely beneficial in remote clinical monitoring, chronic disease management, preventive care, assisted living, and personal fitness monitoring. Termed as a true game-changer for the healthcare industry, the Internet of Things has transformed the sector by lowering costs, improving efficiency, and bringing the focus back to quality patient care.

The IoT in healthcare market includes a number of implanted, wearable, and stationary medical devices used in clinical research organizations, research and diagnostic laboratories, hospitals, clinics, and surgical centers, and defense and government institutions. In the healthcare industry, the Internet of Things can be put to several applications, including clinical operations and workflow management, inpatient monitoring, telemedicine, connected imaging, and medication management. Bluetooth low energy (BLE), ZigBee, satellite, Wi-Fi, near-field communication (NFC), and cellular are some of the key connectivity technologies involved in IoT in healthcare.

Considering that the global healthcare industry has been undergoing several changes in a bid to provide accessible, affordable, and quality patient care, advanced and cutting edge technologies are being developed to help the industry cope with these changes. The introduction of IoT in the healthcare sector has transformed the way health services are being delivered.

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There are a number of factors driving the global market for IoT in healthcare. These include increasing global geriatric population, rising prevalence of various chronic diseases, the surging awareness levels pertaining to the availability of advanced disease management systems, the mounting demand for long-term and short-term healthcare services, and an overall improvement in data management, patient monitoring, and healthcare outcomes. The growing use of smartphones and the improved internet connectivity across the globe are also responsible for the expansion of the IoT in healthcare market.

The global market for IoT in healthcare is geographically segmented into North America, Europe, Asia Pacific, and Rest of the World. North America continues to be the highest revenue generating region and analysts predict that the region is likely to retain its lead in the global IoT in healthcare market throughout the forecast period. The rapid growth of the North America IoT in healthcare market can be attributed to the presence of advanced and sophisticated healthcare infrastructure, major technological advancements in the field of healthcare software and medical devices, increased levels of R&D initiatives in IoT, and high levels of disposable income.

The Asia Pacific market for IoT in healthcare has been identified as the most lucrative region and this geographical segment is projected to witness strong growth in the coming years. Rapid economic growth is one of the primary reasons for the future expansion of the IoT in healthcare in Asia Pacific, especially in countries such as China and India. Other factors impacting this regional market include improvement in healthcare infrastructure, rising disposable income levels, growing presence of IT-enabled healthcare services, increasing affordability of smartphones and various wearable medical devices, and changes in lifestyle habits.

 Adheretech, Cerner Corporation, PhysIQ, Stanley Healthcare, Qualcomm Life Inc., Cisco Systems, Medtronic Inc., GE Healthcare, Proteus Digital Health Inc., Microsoft Corporation, Diabetizer Ltd. & Co. KG, Philips, SAP SE, IBM Corporation, and Honeywell Care Solutions are some of the top companies competing in the global IoT in healthcare market. The nature of this market is immensely oligopolistic, wherein a handful of large, established players dominate the scene with strategies such as collaborative research and development, development of specialized products for specific applications, and acquiring startups with immense potential. This in turn, makes it difficult for smaller players and new entrants to venture into the IoT in healthcare market.

Intrapartum Monitors Exhibits Considerable Growth Majorly due to Increasing Number of Complicated Pregnancy Cases Worldwide

Intrapartum monitors or fetal monitors are deployed during pregnancy, labor and delivery to record the heart rate of the fetus along with strength and duration of uterus contractions. In addition fetal monitoring is performed to identify certain conditions such as cerebral plasy, fetal; death or hypoxic ischemic encephalopathy. External and internal monitoring can be performed to record the heart beat of the baby. External monitoring of baby’s heart beat is facilitated with the help of special stethoscope and more commonly two sensors that measures the baby’s heartbeat and duration of uterine contractions respectively. Sometimes remote monitoring platforms (telemetry) can be employed for external monitoring. Internal monitoring can be performed only post dilation of cervix and in the presence of ruptured amniotic sac.

Internal monitoring is facilitated with the help of a sensor attached to the thigh and an electrode is inserted through vagina and cervix into the uterus and then the electrode is attached to the baby’s scalp. Internal monitoring is more reliable and accurate than external monitoring to keep a track of uterine contractions and baby’s heartbeat. Fetal monitoring or intrapartum monitoring is performed with the help of handheld Doppler device, electronic fetal monitor or sometimes with a Pinard fetoscope. Continuous electronic fetal monitoring is performed with the help of transducers held by stretchy bands against abdomen; however, some patients find it uncomfortable to have the transducers strapped during labor.

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If the fetal heart rate (FHR) is normal then intermittent auscultation or continuous electronic fetal monitoring techniques can be employed in low risk patients. However, if the FHR is abnormal interventions such as maternal oxygenation, intravenous fluid administration are employed. Fetal scalp pH sampling or fetal stimulation is used in the cases where the continuous electronic fetal monitoring is indeterminate and employed to assess the presence of a condition known as fetal academia. Some of the Intrapartum monitoring devices are Fetatrack 360 Cardiotocograph (Ultrasound Technologies, Ltd.), Huntleigh Sonicaid TeamIPTrend Intrapartum Fetal monitor with trend printer, Nicolet VersaLab APM, APM2 (Natus Medical, Inc.) and others.

The product type segment can be further categorized into fetal Dopplers, electronic fetal monitoring and remote fetal monitoring devices. North America and European countries provide lucrative growth opportunities for intrapartum monitors. This is attributable to increased adoption rates, high awareness levels, presence of well equipped healthcare facilities and continuous technological advances in these regions as compared to other regions such as Asia-Pacific and Rest of the World (RoW). Asia-Pacific and Rest of the World provide considerable growth prospects owing to low awareness levels and lack of sophisticated healthcare infrastructure.

 Some of the major factors influencing the growth of intrapartum monitors are increasing need of novel monitoring technologies, increased possibility of high risk pregnancy and increased preference for minimally invasive technologies. The reason for high risk pregnancy cases are changing lifestyles, delayed pregnancy, increasing obesity and others. On the contrary, the reliability of the devices and degree of comfort of the patients are some of the factors that might hamper the growth of the intrapartum monitors. The major companies competing in this market are Allen Medical Instruments Corporation, Analogic Corporation, Med-Electronics, Inc., Paramed Medical Systems, Natus Medical, Inc., Huntleigh Sonicaid and Terason Ultrasound.  

Cleanroom Technology - Growing Prevalence of Contagious and Infectious Diseases Helps in Rising its Trend Worldwide

Cleanroom is an enclosed area or space which has controlled environment in terms of airborne particulates, microbes, contaminants of dust, pollutants, and chemical vapors. Cleanroom also provide regulation of environment in terms of temperature, humidity and pressure. Cleanroom are used in many industries such as pharmaceutical, biotechnology and hardware etc.

The continual advancements in cleanroom technology and the increasing adoption of cleanrooms in the pharmaceuticals and medical devices industries have also driven this market in the recent times. However, the shortage of skilled workforce, coupled with the high cost required for the installation and upkeep of cleanrooms, may limit the application of this technology to some extent in the coming years, notes the market study.

Many factors are responsible for the growth of cleanroom technology market such as increasing healthcare industry, stringent healthcare regulation, demand for quality product, rise in healthcare spending, increased demand for sterilized pharmaceutical product, growing prevalence of contagious and infectious diseases . However, huge financial inputs required for the establishment of cleanroom and constant pressure on healthcare providers to reduce costs are some of the factors that are restricting the growth of this market.

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In 2014, North America emerged as the leading regional market for cleanroom technology due to stringent government regulations pertaining to healthcare and high disposable income of consumers. The region is expected to retain its leadership throughout the forecast period. Europe, which emerged second in the global market in 2014, is also projected to witness a steady rise in the adoption of cleanroom technology over the forthcoming years, states the research report. Asia Pacific, being an untapped market, will present the most attractive growth opportunities to the players in the worldwide cleanroom technology market in the near future. Latin America, on the other hand, will gain from the swift expansion of its medical and healthcare industry.

The major usage of cleanroom technology is in pharmaceutical industry, biotechnology industry, hardware industry, medical devices manufacturers, electronic industry, optical industry, plastic industry, food industry and hospitals. The global cleanroom technology market is highly developed and fragmented market due to the participation of many reputed players. New players are looking forward to invest in cleanroom technology owing to its high demand in the market. Some of the major and prominent players in the market are ; Azbil Corporation, Alpiq Group, Ardmac Ltd , Illinois Tool Works, Inc. , Kimberly-Clark Corporation , E.I. du Pont de Nemours and Company , Royal Imtech N.V. and Taikisha, Ltd.

Neurovascular Intervention - Improving Outcomes for Acute Stroke will Require Patient Education to Encourage Early Presentation

Neurovascular intervention is referred to prevention, diagnosis, treatment and rehabilitation of vascular disorders of the central nervous system with minimal invasive procedures or technologies. Neurovascular disorders are normally treated through micro catheters or by emolization or recanalization of the abnormal vessels.

One of the major factors contributing to the growth of this market is the huge patient pool suffering from various neurological disorders. Other major factors driving the market for neurovascular intervention devices include advancement in device and treatment technology, high incidences of ischemic and hemorrhagic strokes, increasing demand for surgical procedures with minimal invasion, market consolidation and innovative initiatives taken up by leading market players. However, major challenge to the growth of this market is high cost involved in neurovascular intervention treatment.

Geographically, the market is segmented into Asia Pacific, North America, Europe, and Rest of the World. Presently, North America holds a lion’s share in the global neurovascular intervention market, with Europe following its lead. The ever-increasing pool of geriatrics in these regions and the high rate of obesity have both contributed to the growth of the market in these regions. On the other hand, researchers estimate that emerging economies of Japan, China, and India in Asia Pacific along with countries such as Chile, Argentina, and Brazil in Latin America will also lend an impetus to the market due to the improving purchasing power of consumers.

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Some of the key players operating in the global neurovascular intervention market are Johnson & Johnson, Cardiatis, S.A., Abbott Laboratories, Flexible Stenting Solutions, Inc., Boston Scientific Corporation, Bayer AG, Chestnut Medical Technologies, Inc., Covidien PLC, ITGI Medical Ltd., Phenox GmbH, Penumbra, Inc., Stryker Corporation, Sequent Medical, Inc., Terumo Corporation, and NeuroVasx, Inc. The research report provides a granular view of the competitive landscape present in the global market and estimates the bargaining power of suppliers and buyers. Additionally, it also provides an understanding of the threat of new entrants to the existing players. The researchers have also dedicated a chapter to explaining the business and marketing strategies likely to be used by neurovascular intervention market in the coming few years to strengthen their position in the global market.

Neurovascular intervention market is segmented on following basis:

Disease condition

> Endovascular cerebral aneurysm

> Acute ischemic stroke

> Chronic ischemic stroke

> Intracranial atherosclerotic disease

Device type

> Neurovascular embolic coils

> DNeurovascular liquid embolism

> Intracranial stents & flow diverting devices

> Neurovascular thrombectomy devices

 > Carotid stents & embolic protection devices

Sterilization - Surgical Instruments and Medications that Enter an Already Aseptic Part of the Body must be Sterile

The term sterilization refers to any procedure that helps in destroying all forms of microbial life and transmissible agents. Transmissible agents are bacteria, fungi, spore forms and virus. These micro-organisms and transmissible agents are present on the surface of medical instruments, contained in medication, fluid and biological culture media. Sterilization helps in making these culture media infection free by applying heat, pressure, chemical and filtration. This process disables the infectious protein like prions of the micro-organism and hence results in infection free medium.

Sterilization is achieved through various methods such as steam sterilization, heat sterilization, chemical sterilization, radiation and sterile filtration. In steam and heat sterilization, the artifacts which are to be sterilized are placed in a steel container and subjected to high temperature. These containers are incorporated with numerous parts that help in maintaining temperature and pressure inside the container. In chemical sterilization, various chemicals such as ethylene oxide, nitrogen dioxide, bleach, ozone, phthalaldehyde, glutaraldehyde, formaldehyde, hydrogen peroxide, peracetic acid, and silver are used. In radiation sterilization, rays like gamma, ultraviolet, electron beam and X-rays are used. These processes may sometime destroy liquid medium along with the micro-organism. To overcome this situation, sterile filtration is performed where the fluids are passed through very minute pores whose size ranges from 20 to 50 nm. These small pores do not allow the micro-organism to pass since size of these organisms is larger than the pores.

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This market is expected to grow due to rise in safety processes of the various medical institution and research laboratories. In addition rise in number of surgeries and would consequently increase the demand of infection free instruments. In addition, drug preparations also require high sterile medium which would also augment the growth of this market. Moreover, the governments have made stringent rules for various medical institutes to sterile instruments after every use which would also trigger the growth of this market.

 Some of the market players in this industry segment are Roche, Pfizer, Becton Dickinson, Advanced Sterilization Products, Belimed AG and bioMerieux amongst other significant players.