In a new study, Transparency Market Research (TMR) revealed the
fragmented vendor landscape of the global thrombin market, with a
dispersed presence of several players across various nations. The
study has identified companies such as Johnson & Johnson Services
Inc., Pfizer Inc., and Mallinckrodt Pharmaceuticals as dominant
players within the global thrombin market. Other prominent players
operating in the market include Shanghai RAAS blood products co.,
Ltd., Japan Blood Products Organization, and Mochida Pharmaceutical
Co., Ltd. These companies have found a stronghold in Asia Pacific.
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According to TMR, the global thrombin market is likely to reach
US$690.1 mn by the end of 2025, as compared to US$496.1 mn in 2016.
Between 2017 and 2025, the global thrombin market is likely to expand
at a steady 3.8%. Holding nearly 57.5% of the global thrombin market,
North America emerged dominant in 2016. In North America, the US
emerged as a highly lucrative market, exhibiting a rather high
adoption of hemostatic thrombin products influenced by the high
healthcare spending included in overall national budget, easy access
to advanced technologies, and high awareness among consumers. Among
end users, the hospitals segment is likely to contribute the highest
revenue to the global market.
According to the World Health Organization (WHO), road traffic
accidents account for around 1.25 million deaths globally every year.
Globally, hemorrhage or excessive bleeding is responsible for over
one third of pre-hospital deaths and around 40% of deaths within the
first 24 hours of trauma or onset of bleeding. Rise in number of
surgical cases globally is expected to drive thrombin market. The
patient pool with different chronic diseases is also growing rapidly
across the world. This is likely to increase the number of surgical
procedures, consequently propelling the thrombin based hemostasis
products market in the near future. Preoperative hemostasis is vital
and required for effective management of blending during invasive and
other operative procedures which involve the use of blood products
such as thrombin-based hemostats and other hemostatic agents to
enhance patient’s natural blood clotting ability. Adoption of these
thrombin-based hemostats for effective control of bleeding during
surgeries in countries such as the U.S. is likely to fuel the growth
of the thrombin market during the forecast period.
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Thrombin is used in various diagnostic procedures such as coagulation
assays, defibrination of blood plasma, and clotting factor tests.
Thrombin is also used in research and development of fusion of
recombinant proteins, medical, and biochemical research applications.
Rising use of thrombin in diagnostic tools is anticipated to support
growth of global thrombin market and in addition will create new
opportunities in the near future.
High cost as compared to substitute and conventional hemostats is
likely to hamper the growth of the global thrombin market. High cost
of standalone thrombin based hemostats limits adoption of thrombin
therapy in regions such as the U.S., Asia Pacific, and Europe.
Thrombin immunogenicity has been observed in patients in the U.S. and
has become a challenge where all three (bovine, human, and
recombinant) thrombin available in the market. Therefore,
postoperative complications is a major factor hampering the growth of
the global thrombin market. A major challenge faced by protein drug
substances and peptide drug product manufacturers is absence of
uniform and harmonized set of guidelines to define the level of
impurities permissible in peptide therapeutics.
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