One of the aspects
of finding the accurate method for new treatments is selecting a
precise technology platform. Molecules used as active substances can
be classified into two types: large molecules and small molecules.
These two types vary not only in terms of size, but also in terms of
method of manufacture, mechanism of action in the body, and their
preciseness for assured drug forms.
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Large molecules
(biologics), also called as biopharmaceuticals, is a class of drugs
that are based on proteins which have a therapeutic effect. Some of
the key therapeutic proteins which are widely used as biologic drugs
are victoza, rebif, levemir, humalog, Lantus, enbrel, novolog, and
epogen. Biologics consist of more than 1300 amino acids. These can be
as heavy as 150kDa. These are advanced versions of endogenous human
proteins. These large molecules bind to a specific cell receptors
that are associated with the disease process. Usually healthy immune
cells are not attacked in this process. Hence, large molecules have
fewer side-effects compared to classic chemotherapy. These are
extensively used in cancer therapies, cardiac therapies, and diabetes
treatment.
Usually, large
molecules are administered into the patient’s body via infusion or
injection. If they are taken orally, like other proteins and amino
acids in the body, they would be easily digested in the intestines
and the stomach and would become ineffective. Biologicals are
manufactured by employing a biotechnological process; for example,
using genetically modified cells of microbes such as mammalian cell
lines, yeasts, and bacteria.
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The global
large-molecule injectable drugs market is projected to expand rapidly
in the next few years. Some of the driving factors for the market are
increase in the prevalence of chronic diseases such as cancer and
diabetes, rise in the number of drug manufacturers that focus on the
development of biopharmaceuticals to treat different types of cancer,
and increase in investments in R&D activities. On the other hand,
high treatment costs, discontinuation of some of the injectable drugs
for cancer treatment, and strict regulations imposed by some of the
regulatory bodies are likely to restrain the global large-molecule
injectable drugs market during the forecast period.
The global
large-molecule injectable drugs market has been segmented based on
application, distribution channel, and geographical region. Based on
application, the market has been divided into oncology,
cardiovascular diseases, vaccines, and others. Based on distribution
channel, the market has been divided into hospital pharmacies, retail
pharmacies, and e-commerce.
Based on region, the
global large-molecule injectable drugs market has been segmented into
North America, Europe, Asia Pacific, Latin America, and Middle East &
Africa. The market in North America is projected to expand at a rapid
pace in the near future, owing to well-developed health care systems,
proper reimbursement scenario, and adoption of newly advanced
techniques in the region. North America is anticipated to be followed
by Europe and Asia Pacific. Presence of key players, increase in
investments in R&D activities by top market players, alliance of
key market players with research institutes are some of the factors
driving the global large-molecule injectable drugs market.
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Key players
operating in the global large-molecule injectable drugs market are
Medtronic Plc, AstraZeneca plc, GlaxoSmithKline Plc., Biogen Idec,
Novartis AG, Baxter International Inc., Amgen Inc., Sun
Pharmaceutical Industries Limited, Johnson & Johnson, Roche Ag,
and Pfizer.
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