According to WHO (World Health Organization), only 12.5 million blood
donations are collected globally, and approximately half of these are
collected in high-income countries, which is home to 19% of the
world’s population. Limited number of healthy blood donors hinders
the production of MAT kits & reagents which ultimately effects
the growth of the market. Moreover, introduction of pyrogen test in
different applications. Pyrogen test was introduced for
pharmaceutical products such as drugs and immunological products.
Presently, it is being used on medical devices, implants,
purification of water, and food & beverages industries.
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The report offers detailed segmentation of global monocyte activation
tests market based on product type, source, application and end user.
Among the product segment, reagents segment is poised to account for
leading share of the global market during the forecast period from
2017 to 2025. Factors attributed to the higher share of the reagent
segment in the global market include frequent replacements leading to
increasing usage of reagents when compared to test kits. Monocyte
activation tests kits segment is likely to register comparatively
higher growth rate in terms of value in the global monocyte
activation tests (MAT) market during the forecast period owing to
continuous innovations in the product technologies by major market
players.
In terms of source, the monocyte activation tests market has been
segmented into blood based, peripheral blood mononuclear cell (PBMC)
based and cell line based. Blood based segment accounted for the
largest market share in 2016. Blood-based MAT exhibits a natural
human reaction to pyrogens and provides a better estimate of
pyrogenic activity of preparations than the limulus amebocyte lysate
(LAL) or rabbit pyrogen test (RPT). The MAT kit with a cell line is
able to detect all human pyrogens and has an advantage of stability
of the assay based on a cell line. Also, it does not depend on the
blood donor.
By application, the monocyte activation tests market has been further
classified into lipid parenteral, dialysis liquids,
toxic/immune-modulatory drugs, blood products and medical devices.
Medical devices segment accounted the largest market share in 2016
due to the increasing number of medical devices in market demands for
the pyrogen test before approval in the market. Additionally, lipid
parenteral products include vitamins, steroids, and hormones, many of
which are applied intramuscularly using a lipidic carrier. These
products are required to be tested for pyrogen before launch in the
market. This is a key factor driving the segment.
Toxic/immune-modulatory drugs is likely to expand at CAGR more than
15.0% from 2017 to 2025.
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In terms of end-user, the monocyte activation tests market is
segmented into pharmaceuticals industry, biotechnology industry,
medical devices industry and others. Pharmaceutical industry segment
accounted for the major share in 2016 accounting for a share of more
than 30.0% in terms of revenue, while biotechnology industry is
anticipated to grow at higher CAGR during the forecast period due to
the increasing demand of pyrogen testing by biotechnology companies
to determine the presence of bacterial toxins in the process.
Moreover, pyrogen testing has been introduced into medical devices,
implants, purification of water, and food & beverage industries.
These increased application areas are increasing demand for MAT
products.
North America region is expected to witness the highest share in 2016
and is anticipated to grow by a significant growth rate during the
forecast period. Key players domiciled in the region, increase in
research and development activities, and new drug approvals are the
major factors attributed to the dominance of the region. In North
America market U.S. is projected to dominate the market. Europe
region is anticipated to grow by an impressive rate during the
forecast period. Owing to the growth of animal-free endotoxin
detection trend in the region, MAT is expected to gain significant
market share in Europe during the forecast period. In Europe market
Germany is dominant and Spain is likely to expand at highest CAGR due
various research being conducted in the country. Asia Pacific region
is expected to grow with the highest rate during the forecast period.
Increase in focus of key players to expand presence in the region,
large untapped population, and rise in healthcare awareness fuel the
growth of the monocyte activation tests market in Asia Pacific.
Countries such as India, China, and Japan in Asia Pacific are poised
to be the most promising markets for monocyte activation tests in the
near future, expand at high CAGRs during forecast period.
The report also provide profiles of leading players operating in
global monocyte activation tests market include Merck KGaA, Thermo
Fisher Scientific, Charles River Laboratories International, Inc.,
Sanquin, Microcoat Biotechnologie GmbH, Becton, Dickinson and
Company, SOLVIAS AG, and Lonza Group. Innovation is a key strategic
for the leading players, for instance, in March 2016, the Scientist
magazine listed Merck’s CRISPR epigenetic activator among its ‘Top
10 Innovations of 2015’. This innovation was devised from the
understanding that the life sciences research segment lacked an
effective method for the activation of endogenous gene expression.
Additionally expansion through merger and acquisition is followed by
many players operating in this market. For example, in July 2015,
Charles River Laboratories International, Inc. acquired Celsis
International, Ltd., a leading provider of rapid testing systems for
bacterial contamination. This addition to its product portfolio has
expanded the company’s existing portfolio of microbial solutions.
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