Central Nervous System (CNS) lymphoma is also known as primary CNS
lymphoma and microglioma, is a type of intracranial tumor observed in
patients diagnosed with severe immunosupression (typically patients
with AIDS). Primary CNS lymphoma initiates in the spinal cord, brain
or meninges. While, most of primary CNS lymphomas are B-cell
lymphomas and T-cell lymphomas are rare. The sign and symptoms of
primary CNS lymphoma are diplopia, dysphagia, vertigo, monocular
vision loss, progressive dementia and facial hypoesthesia.
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Focal neurological deficit is the most common sign observed in
patients affected with CNS lymphoma, followed by neuropsychiatric
symptoms, headache/nausea/vomiting due to increased intracranial
pressure and seizures. According to World Health Organization (WHO),
in 2012 it was witnessed that the prevalence of primary CNS lymphoma
substantially increased in couple of decades and represented up to 7%
of intracranial tumors around the world for the year. The past
increase was partly assisted with growing prevalence of AIDS as well
as immunosuppression in solid organ transplant patients. According to
a survey carried out by WHO, where they reported that Indolent
lymphomas and diffuse large cell B-cell lymphomas have high
prevalence rate compared to mantle cell lymphoma, peripheral T-cell
lymphoma and composite lymphomas.
There are some tests that are carried out on the samples of tissues
removed from patient’s body such as flow cytometry,
immunohistochemistry and cytogenic analysis. The treatment regime of
CNS lymphoma consists of corticosteroids (e.g. prednisolone),
chemotherapy (methotrexate with leucovorin), radiation therapy (whole
brain radiation therapy) and surgery (stereotactic biopsy).
In patients diagnosed with AIDS highly active anti-retroviral therapy
(HAART) is used, that affects the CD4+ lymphocytes and the level of
immunosuppression observed in the patients. CNS lymphoma is treated
with two types of chemotherapies such as intrathecal chemotherapy or
intraventricular chemotherapy especially depended on the dose of
methotrexate.
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North America was observed to be the largest market for CNS lymphoma
drugs diagnosis and treatment. Advanced technologies and high
healthcare awareness are the major factors driving the growth of this
market during the study period from 2014 to 2020. Europe was observed
to be the second largest market and one of the leading research
destinations for neurological and carcinogenic diseases diagnosis and
treatment. Asia-Pacific and Rest of the World were observed to be the
most potential markets for CNS lymphoma drugs diagnosis and treatment
market.
These regions lack in advanced infrastructure and disease awareness.
The future growth in these geographical regions is expected due to
the presence of emerging economies such as China, India, Brazil and
other countries that primarily prefer healthcare sector for
developmental investment.
This report is a complete study of current trends in the market,
industry growth drivers, and restraints. It provides market
projections for the coming years. It includes analysis of recent
developments in technology, Porter’s five force model analysis and
detailed profiles of top industry players. The report also includes a
review of micro and macro factors essential for the existing market
players and new entrants along with detailed value chain analysis.
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