Colorectal cancer is cancer that starts in the colon or rectum. The
colon and the rectum are parts of the large intestine, which is the
lower part of the body’s digestive system. The colon absorbs water
and nutrients from the food and stores waste matter (stool). Stool
moves from the colon into the rectum before it leaves the body.
Colorectal cancer often begins as a growth called a polyp, which may
form on the inner wall of the colon or rectum. Some polyps become
cancer over time. Finding and removing polyps can prevent colorectal
cancer. During digestion, food moves through the stomach and small
intestine into the colon. Most colorectal cancers are adenocarcinomas
(cancers that begin in cells that make and release mucus and other
fluids). Some of the commonly seen symptoms of colorectal cancer are
blood in the weight loss, fatigue, stool, and irregular bowel
movements. Colorectal cancer is a result of uncontrolled cell growth
that occurs in the appendix, colon, and the rectum region.
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According to American Cancer Society, in United States when men and
women are considered individually colorectal cancer is the third
prominent cause of cancer-related mortality, and the second prominent
cause when both sexes are combined. With the use of fecal occult
blood tests and colonoscopies, which check for blood in the stool the
deaths from colorectal cancer have decreased. Ageing, fatty diet,
excessive consumption of red meat or alcohol, male gender, obesity,
smoking are the most commonly observed causes for colorectal cancer.
Most colorectal cancers originate as a polyp, a growth in the tissue
that lines the internal surface of the rectum or colon and it is
common in people older than 50 years of age, and most are not
cancer.
Increasing adoption of western diet which are high in fat and low in
fiber is expected to boost the growth of colorectal cancer market
over the forecast period. Based on diagnosis, colorectal cancer are
classified as fecal occult blood tests, stool DNA test,
sigmoidoscopy, colonoscopy, virtual colonoscopy, double-contrast
barium enema, others.
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Based on treatment option, colorectal cancer are classified as
surgery, radiation therapy, chemotherapy and targeted therapy.
Surgery remains the most effective treatment for colorectal cancer.
Radiation therapy reduces the chance of cancer spread or recurrence
and is effective as additional or adjuvant therapy either before or
after surgery. The segment is expected to grow rapidly over the
forecast period due to increasing technological advancement and
increasing awareness.
Based on colorectal cancer stage, colorectal cancer has been
segmented into stage 0, stage I, stage II, stage III, and stage IV
(metastatic).
According to National Cancer Institute, in 2016, an
estimated 134,490 people in the United States will be diagnosed with
colorectal cancer and 49,190 people will die from it. In general,
stages 0, I, II, and III are often curable with surgery. Patients
with stage II and III rectal cancer receives radiation therapy with
chemotherapy either before or after surgery. Patients with stage III
colorectal cancer, and some with stage II, receive chemotherapy after
surgery to increase the chance of eliminating the disease. Stage IV
is not often curable, but it effects can be reduced, and the growth
of the cancer and the symptoms of the disease can be managed.
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On the basis of regional presence, global colorectal cancer market is
segmented into five key regions viz. North America, Latin America,
Europe, Asia Pacific, and Middle East & Africa. North America is
expected to lead the global colorectal cancer market for due to aging
population. Due to increase in screening of colorectal cancer and
changes in some risk factors such as a decline in smoking and
consumption of alcohol is decreasing the rate of new colorectal
cancer cases and deaths among adults aged 50 years and above.
Some of the major players in global colorectal cancer market are
Hoffmann La Roche, Debiopharm Group, Merck KGaA, Vaccinogen BD,
AEterna Zentaris, and Keryx Biopharmaceuticals, Inc., etc.
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