A molecular weight marker is used during electrophoresis on the gel,
to identify the approximate size of the molecule. On the gel matrix,
the principle used to identify the molecular weight is that the
migration rate is inversely proportional to the molecular weight.
Therefore, the effective logarithmic scale formed on the gel is used
to estimate the size and weight of the unknown protein or DNA or RNA,
provided that the molecular weight of the marker is already known.
Molecular weight markers can run on either polyacrylamide gel or
agarose gel. Before the commencement of the gel electrophoresis, the
molecular weight markers are loaded in the lane adjacent to the
sample lane, for easy determination of the weight and size of the
unknown samples like RNA or DNA or protein.
The major drivers for the global molecular weight marker market are
increasing number of biotechnology patents and the expenses on
research and development. Also, increased public sector funding for
basic research in biotechnology and pharmaceutical companies is
anticipated to drive the demand for molecular weight markers
significantly. There is remarkable opportunity for the molecular
weight markers market as biotechnology laboratories, life science &
pharmaceutical companies and other end users are constantly utilizing
separation and analysis technology. Currently, there are cutting edge
expansions of profiling applications which are expected to
continuously boost demand for molecular weight markers. Genomics
application is augmenting the growth of the global molecular weight
marker market.
Based on product type, the market for molecular weight markers can be
segmented as RNA markers, protein markers, and DNA markers. The
largest share of the market is held by the segment of DNA markers.
Based on application type, the market can be segmented into nucleic
acid applications and protein applications. Nucleic acid applications
can further be classified as northern blotting, polymerase chain
reaction (PCR), molecular cloning, southern blotting, sequencing and
others. Protein applications can further be classified as gel
extraction, Western blotting and others. The segment of protein
applications is expected to expand during the forecast period 2017 to
2025, while a larger share of the market is held by the nucleic acid
applications segment. Based on end user type, the market for
molecular weight markers can be segmented into clinical research
organizations, pharmaceutical companies, academic institutes, and
others.
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Geographically, the market for global molecular weight markers can be
segmented into Asia Pacific, North America, Europe, Latin America and
the Middle East & Africa. North America holds the largest share
in the global molecular weight marker market. In 2012, North America
accounted for around 40% of global research and development expenses.
Asia Pacific countries have represented significant increase in the
percentage expenditure on development and research & specifically
on molecular biology from 2012 onwards. In the coming years, Asia
Pacific is expected to grow at the fastest growth rate as it
accounted for 30% of the global research and development expenses in
2012.
Globally, the leading companies in the market of molecular weight
markers are Thermo Fisher Scientific Inc., F Hoffmann-La Roche AG,
Sigma-Aldrich, Agilent Technologies, QIAGEN, Affymetrix, Inc.,
Bio-Rad Laboratories, Takara Bio Inc., New England Biolabs, and
Promega Corporation among others. The growth of the market for
molecular weight markers is driven by partnerships between
biotechnology companies, pharmaceutical companies, and academic
research institutes.
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